Dr. Richard E. Frye walks through a double-blind, placebo-controlled crossover trial of a mitochondrial supplement in children with autism. Paper: Hill et al., "A Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism," IJMS 2025.
Dr. Richard E. Frye walks through a new review of how gut bacteria affect mitochondria, the structures that make energy inside nearly every cell. Paper: Frye & Rossignol, "Mechanistic Pathways Linking Gut Microbial Metabolites, Microbial Structural Products, and Host-Microbe Co-Metabolites to Mitochondrial Function," Gut Microbes 2026.
Frye, RE. The Autism File: Biomedical Update. 2015. pp. 28-34.
Rossignol, DA, Frye, RE. Autism Science Digest: The Journal of Autismone. 2011. pp. 21-27.
The Autism Discovery and Treatment Foundation (ADTF) is a 501c3 organization dedicated to solving complex medical problems. The overall aim of ADTF is to improve the lives of individuals and families living with chronic diseases which have been difficult to treat and/or cure. Our focus is on autism and other neurodevelopmental disorders.