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Could Folate Be the Missing Key in Your Child's Progress

Demystifying PANS/PANDAS Podcast 
Nancy O'Hara MD

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Children with autism are showing ‘dramatic improvement’ with this cheap drug — and doctor behind its research says it may one day prevent the disorder

By McKenzie Beard
Published March 19, 2025, 6:00 a.m. ET

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Autism: Arizona doctor claims new drug is helping patients | FOX 10 Phoenix

There is new hope regarding a possible treatment for autism, and it is being spearheaded by a doctor in the Phoenix area.

Child Neurologist Richard Frye has been testing the generic drug Leucovorin as a way of helping folic acid get through to the brain. Folic acid is essential for brain development. Dr. Frye said many patients saw significant improvements in their language skills.

"It's not just talking, but, what we found in our testing is that they were able to understand language in a more complicated fashion and understand the social nuances of language," Dr. Frye said.

Dr. Frye has published his findings in a book, as well as in peer-reviewed studies, and he hopes for additional outside research to confirm and expand on what may be a promising new treatment. FOX 10's Ellen McNamara has more.

(This video is provided for educational and informational purposes only, and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.)

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Doctor claims new drug helps treat children with autism | FOX 5 News

A neurologist in Arizona says the generic drug leucovorin help children with autism absorb folic acid, allowing their brains to develop in a more neuro-typical way. The FDA has not approved the drug for this purpose though.

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Parents say son with autism was nonverbal until trying an off-label drug that treats chemo side effects

By Dr. Céline Gounder
Updated on: September 24, 2025 / 7:50 PM EDT / CBS News

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Dr. Richard Frye on Leucovorin & Autism ד"ר ריצ'ארד פריי על חומצה פולינית, לוקובורין ואוטיזם

Interview with Dr. Richard Frye, a pediatric neurologist and internationally recognized autism researcher, about Folinic Acid, Leucovorin and Autism. Dr. Frye focuses on the biological aspects of autism, including folate pathways, the immune system, metabolism, and mitochondrial function.

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Is a Folate Deficiency Worsening Your Child’s Autism?

Posted by: Potomac Psychiatry
Posted on:  April 13, 2023

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Mitochondrial Dysfunction in Autism Spectrum Disorder

Frye, RE. The Autism File: Biomedical Update. 2015. pp. 28-34.

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A Consensus Statement From the Elias Tembenis Seizures Think Tanks

Frye, RE, Casanova M, Brown GL, Martin V, Edelson S, Coben R, Lewine J, Rossignol D, MacFabe D, Slattery J, Adams JB. Autism Science Digest: The Journal of Autismone. Issue 5. pp. 4-10.

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Seizures in Autism Spectrum Disorder

Frye, RE, Slattery J, Adams JB. The Autism File: Biomedical Update. pp. 24-29.

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Cerebral Folate Deficiency in Autism Spectrum Disorders

Frye, RE, Rossignol D. Autism Science Digest: The Journal of Autismone. Issue 2. pp. 9-15.

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Central Folate Abnormalities

Frye, RE. Autism File: Autism & Treatments. 2017. pp. 25-29.

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Healthy Child Guide

Neurological Health Foundation. 2019.

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Twenty years of autism surveillance: What are the numbers telling us?

Posted by: TACA Now Blog
Posted on:  March 29, 2023

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Mitochondrial Dysfunction and Autism Spectrum Disorders: A Simplified Approach

Rossignol, DA, Frye, RE. Autism Science Digest: The Journal of Autismone. 2011. pp. 21-27.

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Beyond Behavioral ASD Evaluations

Frye, RE, Rose S. Autism File. June-July 2017. pp. 18-21.

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